New Research Challenges Common Fears About Statin Side Effects—Here’s What To Know
We asked experts to separate fact from fiction when it comes to the cholesterol-lowering meds
About 47 million Americans take statins daily to lower high cholesterol, but fear of side effects keeps many others from trying them. Recent studies and doctors’ insights shed new light on which statin side effects are real, which are overblown and what patients can do about them.
Here are key takeaways:
- Between 90 and 95 percent of statin users experience no side effects at all, according to preventive cardiologist Elizabeth Klodas, MD. The confirmed side effects include muscle aches, liver enzyme changes, cognitive fog and a slightly increased risk of type 2 diabetes. But by working with your doctor to adjust your dosage and/or medication, many of these issues can be reversed entirely. (Full story)
- A major study in The Lancet analyzing data from more than 150,000 people found that feared side effects like memory loss, depression, sleep problems, sexual dysfunction and kidney disease occurred at the same rates in people taking placebos. “These symptoms were unlikely to be caused by statins,” said Shannon Chatham, DO. “The findings reinforce that statins may be safer than many people assume.” (Full story)
- Many of the major statin side effects are dose-dependent: Higher doses raise the likelihood of problems. Lifestyle changes like diet and exercise can allow patients to take lower doses, reducing side effect risk.
- CoQ10 supplements for statin-related muscle pain have mixed evidence. Dr. Klodas said there’s “probably a strong placebo effect, which is fine,” but recommends 100 to 200 mg daily of ubiquinol (not ubiquinone) for patients who want to try it. (Full story)
- Statins do not cause significant weight gain. In clinical trials, weight gain was about half a pound over four years, according to cardiologist Tracy Paeschke, MD. Research in JAMA Internal Medicine found some statin users gained weight because they increased fat and calorie intake, feeling falsely protected by the medication. (Full story)
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