Dr: Tirzepatide May Be Even Better Than Ozempic for Weight Loss

Semaglutide medications — such as Ozempic and Wegovy — have become increasingly popular. But tirzepatide medications,such as Mounjaro and Zepbound have recently started stealing the spotlight. Though they tend to cost more, tirzepatide medications may yield better results. So is tirzepatide better than Ozempic? Woman’s World spoke to medical professionals who gave their expert opinions.

Meghan Garcia-Webb, MD, of Weight Medicine MD starts off by reminding readers that results can vary by person: “The pace of weight loss depends on a variety of factors, including how well a patient is tolerating the medication, their pre-existing conditions, and medications they are on,” she explains. “Results are very heterogenous, but for either medication, a good goal is at least 5% weight loss at 12 weeks.”

Although Ozempic was one of the first popular GLP-1s for weight loss, it seems that tirzepatide medications may be more effective. While semaglutide activates GLP-1 receptors, tirzepatide activates two kinds of receptors: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP). This means your blood sugar levels are more closely regulated, which ultimately leads to increased weight loss.

“GIP complements the GLP-1 effect by improving insulin sensitivity, accelerating fat reduction and suppressing appetite,” Baylor University medical instructor Stewart Parnacott, CRNA, APRN, NP, tells Woman’s World. “These synergistic effects amplify tirzepatide’s weight loss outcomes compared to semaglutide.”

Some feel Ozempic has fewer side effects than tirzepatide medications

We received mixed responses regarding which type of medications yields less side effects. Parnacott, for example, feels semaglutide comes with fewer side effects (such as nausea, vomiting and diarrhea). But regardless, with monitoring from a professional and time, he says patients should adjust.

“Tirzepatide’s dual receptor activation can increase the likelihood of worsened GI symptoms in some individuals,” he tells us. “The GIP activation associated with tirzepatide is thought to exacerbate GI issues.”

Others argue tirzepatide has less side effects than Ozempic

But this is up for debate. Other experts, such as Dr. Michael Snyder, Medical Director of the Bariatric Surgery Center at Rose Medical Center and in-house obesity specialist at FuturHealth, feels otherwise. He says tirzepatide medications tend to cause fewer gastrointestinal side effects.

“The additional receptor effect seems to balance its effects on the digestive system,” he says. “Semaglutide’s sole focus on GLP-1 receptors, however, potentially increases the likelihood of these GI side effects.”

Tirzepatide tends to cost more because it targets two pathways

A study from the Journal of Managed Care and Specialty Pharmacy estimates that people spend about $1,000 less per year on Ozempic versus tirzepatide medications. This, according to Parnacott, is largely due to its “dual-action mechanism.”

“Developing a medication that targets two distinct pathways in the body required a more complex production process, extensive clinical trials, and significant research investments,” he explains. “These factors contribute to its elevated price point.”

Its increasing demand is driving up prices, too

But, now that more research is coming out about tirzepatide, it’s becoming more popular. Therefore, Dr. Snyder says higher prices come naturally with a newer, popular medication like Mounjaro or Zepbound. “As a newer medication with greater demand, its pricing reflects the innovation and effectiveness it brings to the market,” he says.

Cost drives some prescribers closer to semaglutide medications

Weight loss medications often aren’t covered by insurance, and proving eligibility for GLP-1s can be difficult. And even for compounded medications, Parnacott estimates a compounded semaglutide medication costs about $297, while a tirzepatide medication goes for $597. Though reviews his patients’ history, goals, and preferences, while explaining the pros, cons, and side effects of both options, he generally recommends the semaglutide medication.

“While I ultimately defer to the patient’s preference, I frequently recommend starting with semaglutide,” he explains. “It is well-tolerated by most patients, produces consistent weight loss, and is more affordable, making it an excellent initial choice for many.”

However, it may depend on any co-morbidities

Dr. Snyder feels differently. He generally chooses between the tirzepatide or semaglutide, depending on underlying medical issues. He says those with higher BMIs might do better on a tirzepatide medication, whereas those with diabetes may do better on semaglutide.

“As per FDA guidelines there are various trade names for these types of medications that are indicated specifically for diabetes and/or weight loss,” he adds. “But, in common practice both are used extensively in weight management. And, the indications for use are increasing regularly as more studies come out showing effectiveness in treating an expanding number of metabolic, medical, and (potentially) psychological issues.”

Ultimately, it may come down to the most effective option

If cost and co-morbidities aren’t a factor, the option that yields the best results is a go-to for some medical providers.

“In general, if access and insurance coverage is equal for both medications, I will usually prescribe tirzepatide,” Dr. Garcia-Webb adds. “Average weight loss is greater and side effects tend to be a little milder.”

FAQs

Is tirzepatide more effective than semaglutide?

Tirzepatide may yield faster, greater results than semaglutide. This is because it targets two hormones instead of one.
Does tirzepatide have side effects?

Tirzepatide medications often come with similar side effects to semaglutide (digestion issues, fatigue, headaches). And while some argue it's worse, other claim the side effects are lessened.