Can Wellbutrin Help With Weight Loss? How the Med Quiets Hunger and Cravings
'It’s more affordable and accessible than many new weight loss medications,' an MD says
Many medications that are commonly referred to as “weight loss drugs” are not actually FDA-approved for this purpose. One of the most popular—Ozempic—is a type 2 diabetes drug that’s often prescribed off-label for weight loss. Now, the antidepressant Wellbutrin is gaining traction for triggering weight loss as a potential side effect. But is it truly an effective way to shed unwanted pounds? And if so, how much can you expect to drop? Our experts have the answers.
What is Wellbutrin?
Wellbutrin is the brand name for the active ingredient bupropion. It’s a non-serotonin based antidepressant that is FDA-approved for major depressive disorder, seasonal affective disorder and smoking cessation, explains psychiatrist Cooper Stone, DO.
Dr. Stone notes that Wellbutrin is sometimes used off-label for weight loss, ADHD, depression associated with bipolar disorder and to treat sexual dysfunction associated with selective-serotonin reuptake inhibitors (SSRIs).
Woman's World Answers
Wellbutrin comes in two formulations: Wellbutrin SR and Wellbutrin XL. The SR version is the sustained-release formulation and is typically taken twice daily. It releases the drug over the course of 12 hours.
The XL version of the Wellbutrin, on the other hand, is the extended release formulation. That means it’s released more slowly into your body over the course of 24 hours. It’s typically taken once daily.
How Wellbutrin aids weight loss
While some antidepressants are thought to potentially increase likelihood of weight gain, Wellbutrin is said to have the opposite effect.
“Wellbutrin can contribute to weight loss by affecting dopamine and norepinephrine, two brain chemicals involved in regulating appetite and energy levels, reducing cravings (especially for carbohydrates) and suppressing appetite,” explains Aalia Al-Barwani, MD, Obesity Medicine Physician and owner of Albidaya Wellness.
Who should consider Wellbutrin for weight loss?
The medication can be particularly helpful for individuals who struggle with both depression and weight management, and those who tend to overeat due to emotional triggers or cravings, Dr. Al-Barwani notes.
“Wellbutrin is also more affordable and accessible than many newer weight loss medications, making it a practical option for some,” she says. “For individuals who may not be candidates for other weight-loss treatments, Wellbutrin offers a safe and effective alternative under medical supervision.”
A quick cost comparison: Without insurance, Wellbutrin costs around $87 a month. Ozempic can cost upwards of $1,000 a month without insurance coverage.
How much weight can you lose on Wellbutrin?
A study published in the journal Obesity found that participants taking 300 mg/day of Wellbutrin SR lost about 7 percent of their body weight over 24 weeks, while those on 400 mg/day lost up to 10 percent. A 10 percent reduction translates to 18 lbs. of weight loss for a 180-lb. person.
That said, Wellbutrin may not be the best option for those looking to lose weight. The combination of bupropion and naltrexone (marketed as Contrave) is FDA-approved for weight loss and has been shown to produce more significant results than Wellbutrin alone for weight management, says Dr. Al-Barwan.
Contrave is formulated specifically to help reduce hunger and control cravings, including those associated with emotions like stress. In one clinical trial, more than half of patients lost 10 percent or more of their body weight after 56 weeks of taking Contrave. Both medications require a prescription, and need to be taken in conjunction with healthy diet and physical activity.
Wellbutrin side effects
Wellbutrin is generally considered safe, but there are a few things to keep in mind. Common side effects of Wellbutrin include nausea, dry mouth, headache, tinnitus and insomnia, says Dr. Al-Barwani. Additionally, anxiety or restlessness may occur, especially at the beginning of treatment. Some people may experience increased mood swings, irritability or suicidal thoughts.
There are also more serious risks, Dr. Al-Barwani cautions, including seizures. Wellbutrin can lower the seizure threshold, especially in individuals with a history of seizures or eating disorders like bulimia.
Is Wellbutrin for weight loss right for you?
It’s important to have an in-depth consultation with your doctor about whether Wellbutrin might work for you and your weight loss goals. It isn’t suitable for everyone, says Dr. Al-Barwani, particularly those with a history of seizures, eating disorders, untreated high blood pressure or adverse medication interactions.
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