The buzz around weight-loss drugs has never been louder or more exciting, especially when it comes to a brand new option called retatrutide or “reta”—stuff so powerful it’s basically threatening to put weight-loss surgeons out of business. A lot of us have questions: What is retatrutide? Where do we get it? Could it really be a better choice than other GLP-1 medications like Ozempic or Zepound? 

For answers, we turned to Terry Dubrow, MD, who has spent the last 18 months studying and testing retatrutide and other GLP-1 medications. (Yes, he’s a famous plastic surgeon and star of Botched; GLP-1s are his new passion, and he recently passed his obesity medicine board exam with flying colors!) Here, Dr. Dubrow—who has personally tested retatrutide so he’d have firsthand knowledge when discussing it with patients—shares the latest on the blockbuster drug, plus everything else you need to know about your GLP-1 options. 

Check out Dr. Dubrow, who appears on the July 2, 2026 cover of of Woman’s World magazine, where he shares the latest on retatrutide and GLP-1 drugs. Get your copy here!

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First, what are GLP-1s exactly?

It’s the nickname for a category of prescription drugs including Ozempic, Wegovy, Mounjaro, Zepbound, retatrutide and more. They all spike the natural hormone GLP-1 (short for glucagon-like peptide-1), dramatically improving blood sugar control and appetite. Insurance often won’t pay for the pricey meds, but they’re transforming the weight and health of millions, even working for many people who’ve struggled to slim down for years or decades. “They’re the most impactful drugs in the history of medicine,” Dr. Dubrow says. 

Dr. Dubrow’s guide to GLP-1s—and why retatrutide could change the game

Retatrutide has the most buzz, but it will be impossible to get a legal prescription for the weekly injectable for at least several months, as the final phase of testing is being analyzed and must still be sent to the FDA for approval. So let’s dive into why it may be worth the wait and what the best (and cheapest!) alternatives are. 

Wellness

She Lost 90 Lbs With Zepbound—Here’s How She’s Keeping It off Without Meds

Ozempic, Wegovy, Mounjaro, Zepbound—this new wave of medications boosts levels of the hormone GLP-1, dramatically shrinking appetite, improving blood sugar and reducing body weight by up to 26 percent. Experts say results can be life-changing. Yet research more than half of users discontinue the meds due to high cost, side effects or other reasons. It’s […]

Retatrutide is the drug of the future

Drug maker Eli Lilly has released sneak-peek findings from the Phase 3 trial, and retatrutide benefits seem wildly impressive so far. FDA approval for this blockbuster option is expected as early as this winter, “but all of Beverly Hills already takes the black-market version,” says Dr. Dubrow. It’s called a triple agonist because it acts on three hormones: GLP-1, GIP and glucagon. Glucagon is “a hormone that dissolves fat.” After Dr. Dubrow personally tested retatrutide for research purposes, this is his verdict: “It’s going to change everything.”

Advantages: Results rival gastric bypass. “Weight-loss surgeons are already feeling the impact,” he says. “Some practices are decimated.” Reta also seems to preserve muscle mass better than other GLP-1s. On top of that, findings have been released that show retatrutide reduces pain from knee osteoarthritis an average 74 percent. And a Nature Medicine study found it may reduce liver fat by up to 82 percent.

Drawbacks: Like all GLP-1s, it has side effects, with nausea and other GI problems being most common. There may be risk of cardiac arrhythmias; final data from Phase 3 clinical trials has yet to be released. And some people have dropped out of studies because they feel they’re losing too much weight.

Typical results: A 12-mg dose of retatrutide led to an average loss of 71 pounds in 68 weeks, per early results from clinical testing.

Who it’s best for: The 15 percent of folks who don’t lose at all or don’t lose much on tirzepatide—plus anyone who wants the fastest results possible when it comes to weight reduction, says Dr. Dubrow.

Retatrutide + a myostatin inhibitor—the ‘holy grail’ GLP-1  

Retatrutide hasn’t even been approved, yet a jaw-dropping twist is already in the works. Scientists are now attempting to add a compound called a myostatin inhibitor to reta, creating a kind of super-duo medication, says Dr. Dubrow. 

He notes that upgraded reta will turbocharge fat burning by targeting GLP-1 and other key hormones, and then the myostatin inhibitor will turbocharge our ability to build muscle. So we’ll build muscle as we burn lots of fat. It’s a one-two punch that promises to make us leaner, stronger and fitter than we ever dreamed possible. In development by Eli Lilly, “it’s the holy grail of weight-loss drugs,” says Dr. Dubrow. He estimates it’s about three years from approval. 

Mounjaro & Zepbound—the most powerful GLP-1 for now 

Both Mounjaro and Zepbound are brands of tirzepatide, which acts on GLP-1 plus GIP, a hormone that helps improve fat metabolism. 

Advantages: “It’s the most powerful option for now,” says Dr. Dubrow. So much so that for some of us, a 2.5-mg low dose or “microdose” of tirzepatide (which costs $299 per month from the LillyDirect pharmacy) may be more effective and cheaper than high doses of alternatives like Ozempic and Wegovy. 

Drawbacks: Higher doses from LillyDirect are $449 per month (and this is for vials and needles, not easy-to-use pens). You may, at least for now, be able to find generic tirzepatide for about $299 monthly—but producing generics is a legal gray area, and this option may not be around much longer.

Typical results: Expect losses of anywhere from 21 to 32 percent of body weight, per studies published in Nature Medicine and elsewhere.

Who it’s best for: Until new medicines like retatrutide are approved, Dr. Dubrow thinks most people hoping to lose weight should start with this option.

Ozempic & Wegovy—a solid, cost-effective choice

Both Ozempic and Wegovy are brands of semaglutide. Great at normalizing blood sugar, they’re most famous for quieting “food noise”—those constant thoughts of food that drive us to eat when we’re not hungry.

Advantages: Wegovy is typically less expensive than other GLP-1 options, about $349 per month for 2.5-mg injection pens from NovoCare pharmacy. There’s also a new high-dose Wegovy for $399 monthly. Wegovy also comes as a daily pill for $299 monthly, making it ideal for those who don’t do needles. Generic semaglutide, though in legal limbo, currently goes for about $199 a month.

Wellness

GLP-1s Can Reverse Prediabetes for 95% of Us—and Speed Weight Loss in Women

An astonishing fact about the GLP-1 meds that are helping millions lose weight: Tirzepatide, the active ingredient in Mounjaro and Zepbound, has the power to stop prediabetes in its tracks for 99 percent of us, per a study in the New England Journal of Medicine. Though the effect rarely makes headlines, it could prevent devastating […]

Important note about Ozempic: Novo Nordisk charges self-pay patients $499 a month for 2-mg of Ozempic—that’s $150 more than they charge for a 2.5-mg dose of Wegovy, which is the exact same drug. 

Drawbacks: Semaglutide is less effective than other options. And unlike other GLP-1s, it works on just one chemical pathway, which can be harder on the body and may increase side effects like nausea and GI distress, says Dr. Dubrow.

Typical results: Studies, including findings in the New England Journal of Medicine, show losing anywhere from 15 to 20 percent of body weight can be expected with weekly injections. Separate research shows losing about 14 to 17 percent is typical with the pill.

Who it’s best for: Those who must keep costs low. Dr. Dubrow also likes it for weight management (aka maintenance) after slimming down on a stronger drug.

GLP-1 success story: Jill Sweeney, 54, lost 130 lbs

After lifelong weight issues, Jill Sweeney was diagnosed with raging diabetes and put on Mounjaro. Did her insurance pay? Not at first, but they eventually relented. The first signs it was helping: Jill’s A1C was cut in half “and my food noise and hunger were gone,” recalls the Georgia mom and healthcare trainer, 54. Yet as a frequent traveler reliant on takeout, weight loss was slow despite repeated dose increases.

Luckily, Jill’s insurance offers Virta Health, a program to help people lose weight and reverse diabetes. Did Jill’s free coach make her give up McDonald’s? Nope! Instead, Jill was encouraged to aim for 91 grams of protein and up to 30 grams of carbs a day. She went for high-protein, low-carb picks like Cheesecake Factory’s Chicken Madeira, Jersey Mike’s Sub in a Tub, Chick-fil-A grilled nuggets and Starbucks egg bites. Want ideas for a specific restaurant? “Just ask ChatGPT!” she says. “I was supposed to use fat to feel satisfied, and I ate a lot of it at first.” She still shed a motivating 12 pounds the first week.

She’s now down 130 pounds and more energized and active than ever. “I got off my diabetes and blood pressure meds too.” Jill points out this wasn’t her first attempt at a lower-carb diet. It was just her first successful attempt. She credits both Virta and Mounjaro: “I wouldn’t get to live this life without them.”

A version of this story appears in the July 20, 2026 issue of Woman’s World.

Imagine spending thousands of dollars on weight-loss medication—only to discover months later that it doesn’t work for your body. Frustrating, right? Now, for the first time, a test based on cutting-edge Mayo Clinic research can predict if your unique body will respond favorably to GLP-1 drugs. And it could change the weight-loss game forever, helping people save precious time and money on their wellness journey. Here’s everything you need to know about GLP-1 testing, including insight from doctors who use this tool with patients and a testimonial from one grateful user.

How does this GLP-1 test actually work?

Mayo Clinic researchers developed this DNA-based obesity test to identify genetic weight-loss types. Since 2023, only specialty obesity clinics could offer the test. But now, Phenomix Sciences offers it directly to consumers through a simple mail-in cheek-swab kit.

The test is based on groundbreaking science that shows people’s weight-related tendencies fall into four distinct categories or phenotypes—some that respond well to GLP-1 treatment and others that don’t. It’s the only consumer test on the market that identifies these four genetic types. The thinking: Before shelling out cash on weight-loss drugs, this GLP-1 test helps you and your doctor determine whether they’ll actually work for your system.

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How to get the GLP-1 test for yourself

Step 1: Visit myphenometest.com and complete a short questionnaire to confirm the test is a good fit. If so, you can make a one-time payment for the MyPhenome test. It costs $299 and isn’t currently covered by insurance, but the results could help you save thousands on ineffective weight-loss drugs down the road.

Step 2: A kit will be mailed to your home. Use it to collect a painless cell sample with a cheek swab, then send the sample back in the provided prepaid mailer.

Step 3: Receive a personalized MyPhenome report within about three weeks through a secure patient portal. It reveals which of the four genetic types may be driving your weight gain—plus specific treatment recommendations matched to your unique biology.

Step 4: Share your results with your healthcare provider to inform future weight-loss guidance and treatment decisions.

What your results will reveal about your body

Based on genetic-type science, everyone either falls into one of these four phenotypes. You may be a:

Hungry Gut type

People in this genetic group tend to have fast gastric emptying, so they don’t sense the normal fullness cues that people feel as their stomach fills up. As a result, they often keep eating. GLP-1 receptor agonist medications often work well for people with this genetic type.

Hungry Brain type

People in this group always feel hungry because their body sends stronger hunger signals. So they need to eat more calories than their peers to reach maximum satisfaction. Some medications such as Qsymia (phentermine-topiramate) can help here more than GLP-1s.

Emotional Hunger type

Individuals in this group tend to overeat in response to emotional triggers such as stress, anxiety or depression. Often, the pleasure and reward centers in their brain respond intensely to sugar in processed foods, creating powerful cravings. Cognitive therapy and medications that include an antidepressant effect such as Contrave (naltrexone/bupropion) can help here the most.

Slow Burner type

People in this group often show characteristics of multiple types combined with a genetically slower metabolic rate, meaning they don’t burn calories as quickly as others. More research is needed to know what works best, but preliminary data suggests resistance training to build muscle may be most powerful here.

Why this test could be a game-changer

Experts now recognize that obesity is a complex disease with multiple causes, and what works for one person may not work for another. A study in the journal Obesity shows that phenotype-guided weight-loss treatments are twice as effective as traditional one-size-fits-all approaches.

Plus recent research from the Journal of the Endocrine Society finds that as many as 30 percent of GLP-1 medication users won’t succeed at achieving meaningful weight loss. That frustration means wasted money and time that could have been spent on more targeted approaches.

Mark Bagnall, CEO of Phenomix Sciences, the maker of the test, says, “GLP-1s have transformed obesity treatment, but they’re not the only option, nor are they the right option for every patient.”

How this GLP-1 test helped Jessica

Want to see how this works in real life? Minnesota mom Jessica Layeux, 52, knows the frustration of spending months and thousands of dollars on a GLP-1 that didn’t work. She was taking Zepbound. “But I wasn’t losing weight,” she recalls. “My doctor then recommended the MyPhenome test, which showed I had characteristics of both ‘hungry brain’ and ‘hungry gut.’ Based on those results, my treatment plan was adjusted.” She tried phentermine, a completely different class of medication that works on suppressing appetite and costs much less than GLP-1s.

That genetic insight proved priceless. “For the first time, I felt like I understood why I was struggling. Within a month of adjusting my treatment, I lost 20 pounds.” She raves, “Personalized obesity care helped me find an approach that finally worked for me.”

What medical experts say about GLP-1 testing

“MyPhenome is a valuable tool in my practice,” says Natalie Ikeman, PA-C, president of the Minnesota Obesity Society and an advisor for Phenomix. “It helps us better understand the genetic drivers behind each patient’s condition.”

As awareness of GLP-1 medications has grown, their use has skyrocketed in recent months. “With increased prescribing, I’ve also noticed a tremendous variability in patients’ response both initially at the lowest dose and over time with slow and continued dose escalation,” reveals obesity specialist Melina Jampolis, MD, who spent a decade studying the connection between genetics and nutrition. After seeing the research, she is now convinced of the vital role genes play in weight loss and uses this test with patients.

“It explained why some patients essentially stopped responding after four to six months despite achieving the maximum dose,” Dr. Jampolis says. “My patients felt very frustrated and disappointed when their response to the medications stopped. They are very relieved and happy to know that they were not doing anything wrong, their bodies were just genetically different.”

And good news if the test indicates that GLP-1s aren’t ideal for your body: With the test’s insights, your doctor can help guide you to different treatment options that may work better for your type.

The bottom line

“I now encourage all of my patients who have a considerable amount of weight to lose to undergo this testing, so we don’t waste time or money on GLP-1 medications or continued dose escalation that is likely doomed to stop working after 6 months,” Dr. Jampolis says. Remember, learning how your unique genes affect your metabolism can increase your chances of lasting weight-loss success.

GLP-1 alternatives are getting fresh attention after Stanford researchers identified a naturally occurring peptide called BRP that suppressed appetite in animals without the nausea, constipation and muscle loss that have driven so many people off Ozempic. Here’s what the science actually shows and what’s worth knowing before you get too excited.

What is BRP and how does it work?

BRP is a 12-amino-acid peptide your body already makes naturally. A March 2025 study in Nature led by Stanford Medicine found it reduced food intake by up to 50% in mice and minipigs within an hour of a single injection. Stanford scientists found BRP using an AI tool called Peptide Predictor that scanned more than 2,600 human peptide fragments to find ones that might act as hormones.

Unlike semaglutide, the active ingredient in Ozempic, BRP acts specifically in the hypothalamus, the brain region that controls appetite and metabolism, rather than hitting receptors across the brain, gut, pancreas and other tissues. The study was funded by the National Institutes of Health.

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Wellness

MD: You Can Get the Weight Loss Benefits of Ozempic Without the Side Effects

Who needs injectables when these natural GLP-1 alternatives work in the same way...even more powerfully!

Why does where it acts in the body matter?

That targeted action is exactly why researchers are excited. Ozempic and similar drugs bind to receptors throughout the body, which is why side effects show up in so many different ways. A RAND Corporation survey of 8,793 U.S. adults released in August 2025 found roughly half of all GLP-1 users experienced nausea and about one-third experienced diarrhea.

A University of Pennsylvania team scanned 400,000 Reddit posts from about 70,000 GLP-1 users and published findings in Nature Health in April 2026 showing 44% reported at least one side effect. Notably, reproductive symptoms including menstrual irregularities appeared to be underreported, which matters because GLP-1 prescribing has grown fastest among women aged 30 to 49.

The Reddit sample skews younger and male, so there are limits to what it shows, but clinicians say the pattern tracks what they hear in practice. In animal tests, BRP triggered none of those complaints.

Does BRP have side effects in humans?

Nobody knows yet, because BRP has not been tested in people at all. The “no side effects” finding is based entirely on animal studies. Until BRP reaches human clinical trials, that question simply can’t be answered.

Weight Loss

The Latest on Natural Ozempic Alternatives: How To Lose Weight Without GLP-1s

Weight loss drugs like Ozempic and Wegovy work by boosting a hormone called GLP-1 that controls blood sugar, curbs hunger and aids weight loss. And while GLP-1 drugs have been game-changers for weight management and other impressive health benefits, they can also be pricey and come with unwanted side effects. Fortunately, research shows that certain […]

When will BRP be available?

Not for a while. BRP has not been tested in humans, has not been reviewed by the FDA and is not available anywhere. Stanford says human trials are expected soon, but even in the best case scenario new drugs take several years to move through safety and efficacy testing before approval.

Two things worth knowing before drawing any conclusions. Lead author Katrin Svensson co-founded Merrifield Therapeutics, the company planning to commercialize BRP, and both she and co-author Laetitia Coassolo hold patents related to BRP peptides. That doesn’t invalidate the research, but it’s context worth having.

Also, “natural” here means the body already produces this peptide, not that you can buy it anywhere. There’s no supplement version, nothing to order online and no food that contains it.

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Natural Ozempic? 6 GLP-1 Foods That Mimic the Shot Without the Cost!

Popular weight loss drugs like Ozempic and Wegovy work by artificially increasing levels of a natural anti-obesity/anti-diabetes hormone called glucagon-like peptide 1 (GLP-1). Can we reap its slimming benefits without pricey injections? In a word: Yes. Research shows that certain “GLP-1 foods” can increase secretion of the hormone by up to 900 percent. And beyond […]

Is there anything available now that works similarly?

For now, the only approaches with real clinical backing for metabolic health are the GLP-1 drugs themselves and lifestyle strategies like changing what and when you eat. If you’re on a GLP-1 drug and struggling with side effects, that’s a conversation worth having with your doctor sooner rather than later. And understanding how eating patterns like intermittent fasting fit into that picture is worth exploring while BRP works its way through development.

If you’ve struggled mightily to lose weight and keep it off long term, bestselling author Mary Kay Andrews, 71, can relate—and she may even give you hope for a healthier future. Because after decades of yo-yoing, she’s down 65 pounds and is maintaining with ease. Her secret? Pairing budget-friendly Costco and yard-sale strategies for protein shakes and home gym equipment with microdosing GLP-1 medication to keep costs down. “It has been a game changer for me,” shares the Georgia grandmother. Keep reading for her inspiring story. 

Mary Kay’s late mom motivated her to make changes

The “Queen of the Beach Read,” Mary Kay has penned 33 titles, her newest being the secrets-and-sexy-Irishmen romp Road Trip. When she was promoting Summers at the Saint in 2024, Mary Kay was well over 200 pounds, recovering from a knee replacement and using her asthma rescue inhaler five times a day. “I was about to turn 70, and my mom died of a heart attack at that age,” she shares. “I started thinking, ‘I need to make changes.’”

The hitch: She’d already been exercising regularly with a physical therapist and the scale hadn’t budged. As for her diet, she’d been trying to eat better for most of her life. What else could she do? She started researching, and the internet suggested trying a telehealth service to get started on GLP-1 therapy. She figured it couldn’t hurt. After signing up, she was put on the lowest dose of the weight-loss drug Zepbound. It was just a “microdose” meant to give her body time to adjust to the medication. But it had a huge impact.

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Wellness

She Lost 90 Lbs With Zepbound—Here’s How She’s Keeping It off Without Meds

Ozempic, Wegovy, Mounjaro, Zepbound—this new wave of medications boosts levels of the hormone GLP-1, dramatically shrinking appetite, improving blood sugar and reducing body weight by up to 26 percent. Experts say results can be life-changing. Yet research more than half of users discontinue the meds due to high cost, side effects or other reasons. It’s […]

Microdosing GLP-1 can mean huge savings 

Like the drugs Ozempic, Wegovy and Mounjaro, Zepbound spikes the hormone GLP-1 to kill appetite and dramatically improve blood sugar. Insurance often won’t cover the pricey prescriptions, which run about $449 per month. But Mary Kay’s 2.5 mg mini-dose is usually $299, with some companies selling a generic (tirzepatide) for $199. It’s still not cheap, yet, says Mary Kay, “it’s way cheaper than all the meds I’d need if I didn’t lose weight.” And lose she did: 12 pounds that first month, 65 pounds in a year, all on the 2.5-mg dose of the medicine.

Will a low dose work for everyone? No, others still require higher doses to see results. But there’s a chance it’ll be just the boost you need, especially if you’re over age 50. “Older adults may be more sensitive to medications, so lower doses can provide meaningful appetite regulation and weight loss,” notes Cuilan Li, MD, PhD, a women’s health expert who shares GLP-1 expertise on JustAnswer.com.

For Mary Kay, microdosing her GLP-1 with weekly injections eased hunger so much that “sometimes I’d forget to eat,” she says. It also took the edge off her obsession with carbs. In the past, “I’d say, ‘If I write 500 words, I can have a bag of M&Ms,’” she recalls. And now? “I still like sweets, but I’m happy with smaller amounts less often.” So she was finally able to stick to commonsense choices, building meals around protein and produce with healthy fat or fiber-rich starch on the side. There was also her new go-to morning meal…

How a $2 Costco shake speeds fat loss

Everyone on a GLP-1 is told to keep protein intake up as appetite drops. Why? Because if you skimp, your body breaks down muscle to meet its needs, which tanks strength and metabolism, says Dr. Li.

Duke University research shows that older adults who get about 1 gram of protein for every pound of their body weight preserve muscle and lose weight fastest. So Mary Kay started stocking up on Premier Protein shakes from Costco that cost around $2 each. “I’ll blend it with kale, maybe half a banana,” she says. The drink is tasty and a perfect way to get protein when she’s not hungry for a full meal.

Mary Kay’s secret to scoring cheap home gym equipment

Beyond microdosing a GLP-1 and filing up on protein, Mary Kay also learned activating her muscles was key. She started small, just walking as far as she could manage. But as pounds came off and her pain and breathing got better, she found herself aiming for 10,000 steps a day. “I walk to Dateline podcasts,” she shares. “I don’t want to stop until I know what happens to the murderer!”

She didn’t stop there. “My orthopedist recommended an exercise bike,” she recalls. “I got one on Facebook Marketplace for $50!” Mary Kay, who loves to hunt for treasures at places like flea markets and estate sales, was so thrilled, she set out to find more cheap home gym equipment. At a yard sale, she found “a nice treadmill for next to nothing.” She later scored a cheap weight bench. She adds that Facebook’s local “Buy Nothing” pages often have weights free for the taking.

And the benefits go beyond your wallet: A combo of muscle-building activity and eating plenty of protein helps maintain bone density in older women, says Jennifer Cheng, DO, chief of endocrinology at Jersey Shore University Medical Center. It also provides extra protection for muscles, “ensuring the weight you lose is primarily fat.” A New England Journal of Medicine study of GLP-1 users found exercise doubles body fat loss compared to meds alone.

“I’ve gotten so much stronger,” marvels Mary Kay. “I could barely lift a soda can when I started!”

Weight Loss

Ozempic Prices Are Soaring—Experts Reveal 5 Ways to Save on GLP-1 Meds

Not long ago, the FDA announced there’s no longer a shortage of Ozempic, Wegovy, Zepbound or similar drugs used for weight loss. Is that good news for the millions of us who struggle with excess pounds? Not exactly. During the shortage, pharmacies were allowed to make special low-cost ‘compounded’ versions of the meds. But that […]

From size 18 to size 8: Why she’s going public 

This is the first time Mary Kay is publicly sharing the full details of her health journey. For a while, she held back. She knows some folks have biases against GLP-1s and she wasn’t ready for criticism. But now she feels changed.

“Taking charge of my health has made me more confident,” she says. “It’s made me more assertive in saying, ‘I’m worthy of respect and love.’” And as she gets ready to promote her book Road Trip, she wants to pay her good fortune forward. Do you see a little of yourself in Mary Kay? “Then I think the big message is: Don’t count yourself out. It’s never too late to take control of your health. And it feels so good!”

Check out Mary Kay’s new book Road Trip

This story originally appeared in the June 8, 2026 issue of Woman’s World

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When it comes to weight loss, moving the scale can feel daunting. You’re trying to figure out the best diet plan, exercise routine and how to maintain positive mental health through it all. It can feel even more overwhelming when you have a larger amount of weight to lose. But there’s a new treatment that has experts buzzing about the benefits: a once-weekly injection called retatrutide with early results comparable to weight loss surgery. We asked an expert to break down everything you need to know about this promising medication making waves in weight loss research.

What is retatrutide?

Rekha Kumar, MS, MD, endocrinologist, obesity medicine specialist and senior medical advisor at Found, describes Eli Lilly’s retatrutide (nicknamed “reta”) as a “next-generation” weight-loss medication that is still awaiting FDA approval, but currently in late-stage clinical trials.

“It’s a once-weekly injectable being studied for obesity and related metabolic conditions,” adds Dr. Kumar. “What makes it stand out is that it targets three hormone pathways simultaneously: GLP-1, GIP and glucagon, [which are] involved in hunger, fullness, blood sugar [regulation] and metabolism. Current medications like Ozempic or Zepbound only hit one or two of those pathways, which is likely why early data is showing more dramatic results.”

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Weight Loss

GLP-1 Pills Could Replace Injections—Here's When They'll Be Available

Imagine if losing weight were as simple as swallowing a daily pill—no needles, no injections and no anxiety. If you’re among the 25 percent of adults who fear needles, per Harvard Health, or if self-injecting just doesn’t sound so fun, then this news will feel like a game-changer: GLP-1 pills are in development right now, […]

New research on retatrutide benefits for weight loss

According to NBC News, the newest phase 3 clinical trial found that people taking retatrutide lost up to 85 pounds, essentially 30 percent of their body weight, which is not too dissimilar to the percentage of body weight people lose after bariatric surgery, which is 25 to 35 percent within one to two years, per NBC News referencing data from Circulation Research.

During the 80-week trial, participants lost an average of 28 percent of their body weight (roughly 70 pounds) on the highest dose of retatrutide, while nearly half shed 30 percent of their weight or more.

What explains these groundbreaking results? “Retatrutide appears to be more effective than earlier medications because it addresses more of the biology driving obesity at once,” says Dr. Kumar. “Hunger, cravings, metabolism, blood sugar regulation—it’s hitting all of those levers simultaneously rather than just one or two. That matters because obesity is a complex chronic disease with deep biological roots, not simply a willpower problem. The more pathways we can address, the more powerful the response.”

Dr. Kumar refers to the early retatrutide data as remarkable from a clinical perspective. “Even a five to 10 percent reduction in body weight meaningfully improves blood sugar levels, cholesterol, blood pressure and sleep apnea,” she adds. “When you’re approaching 25 to 30 percent, you’re entering territory we historically associated only with bariatric surgery, not medication. That’s a genuinely historic shift in what’s possible for obesity treatment.”

How retatrutide benefits the future of obesity treatment

GLP-1s like retatrutide are changing the conversation around obesity treatment and weight management. “What these medications collectively reinforce is something obesity medicine specialists have advocated for years: Obesity is a chronic disease driven by biology, hormones, genetics and metabolism. Not a character flaw,” Dr. Kumar adds. “The treatments are finally catching up to science. Retatrutide, if approved, could represent the most significant advancement in this space yet.”

And while the comparison between retatrutide and bariatric surgery is exciting, Dr. Kumar reminds us the two methods, and what we know about them, are still very different. “For some patients, retatrutide may approach surgical-level weight loss without surgery,” says Dr. Kumar. “But these are fundamentally different tools. Bariatric surgery has decades of long-term outcome data behind it and can be life-changing, though it carries surgical risks and permanent changes to the digestive system. Retatrutide is far less invasive, but we still need longer-term safety and durability data—including what happens when patients stop the medication. It’s not an either-or conversation yet; it’s an ‘and’ for the field.”

When will retatrutide become available? 

If you’re feeling excited by the new research on retatrutide, you may be wondering when it will become available. Dr. Kumar offers both caution and some insight. She reminds people that retatrutide is still awaiting regulatory approval by the FDA and is currently unavailable outside of clinical trials. She also advises against trying compounded versions promoted on social media that have not been FDA approved.

“The TRIUMPH-1 phase 3 trial results are a major milestone,” says Dr. Kumar of the latest study on the benefits of retatrutide. “The next step is for Eli Lilly to submit a New Drug Application to the FDA, a review process that typically takes about a year, which puts realistic approval in 2027 at the earliest.”

Who might benefit from retatrutide?

Dr. Kumar says that ultimately, a medical provider who knows your full medical history can help determine whether retatrutide is a good fit for you. However, based on current research, retatrutide may be a good fit for those who:

• Are obese or overweight
• Have type 2 diabetes
• Live with fatty liver disease
• Have high blood pressure
• Have sleep apnea

She adds it may not be a good fit for those with:

• A history of pancreatitis
• Certain thyroid cancers (such as medullary thyroid carcinoma)
• Specific digestive conditions (such as severe gastroparesis)
• People who are pregnant or breastfeeding

Similar to many medications, retatrutide is not without side effects. Dr. Kumar says the known side effects are similar to those associated with existing GLP-1 medications and may include:

• Vomiting
• Diarrhea
• Constipation
• Nausea

Weight Loss

What Contrave Weight-Loss Medication Really Does for Women

If you’ve tried the usual weight loss approaches—eating well, moving your body and tracking what you consume—but you’re still struggling to reach your goal, you may be considering the increasingly popular route of weight loss medications. Many women find that medications like GLP-1s (think: Ozempic) can be the extra support they need to finally feel […]

The bottom line on retatrutide benefits for weight loss

Retatrutide represents a potentially groundbreaking option for people struggling with obesity: one that could deliver results previously only possible through surgery. While it’s not yet available and won’t be right for everyone, the early research is genuinely exciting. If you’re interested in weight loss medications, talk with your healthcare provider about what options might work for you now, and keep retatrutide on your radar as it moves through the approval process.

You finally took the plunge and started taking a GLP-1 drug to improve your health. You’re keeping up with your GLP-1 pill or injection schedule, and you can’t wait to see results in your blood sugar and weight loss. But the weeks have turned into months, and although the medication seems to be working well for everyone around you, your GLP-1 is not working. What gives?

While there are several reasons you may not be seeing your desired results from a GLP-1, new research points to a cause that might not be on your radar yet: your genes. We asked experts to explain everything you need to know about this research, including what this gene could mean for you and alternatives that may help you manage your health conditions or support weight loss. 

What is a GLP-1?

“GLP-1 receptor agonists are medications that mimic a natural hormone in your body called glucagon-like peptide-1 [GLP-1],” explains Thomas Tsang, MD, MPH, Chief Medical Officer at Omada Health. “From my perspective, these medications have an effect both on your brain and your metabolism because they act on areas that regulate appetite and reward while also affecting how your pancreas releases insulin and how quickly your stomach empties.”

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“Many people think about GLP-1s as weight loss drugs, but their benefits can go far beyond that to include improved blood sugar control, better heart health and decreased appetite,” adds Dr. Tsang. 

Weight Loss

Do GLP-1 Patches Work? Get the Skinny on Natural Ozempic Alternatives

From supplements to injectables to belly-fat blasting beverages, there are plenty of products that claim to speed weight loss. The newest entrant into the diet-culture arena? GLP-1 patches, topical adhesive patches worn on your arm or abdomen that claim to deliver natural weight-loss revving nutrients through the skin. But do these GLP-1 drug alternatives made […]

Common reasons your GLP-1 is not working 

If you’ve been on a GLP-1 medication for months without seeing meaningful changes in your health or significant weight loss, you’re likely wondering what’s going on. Kardie Tobb, DO, MS, FASPC, FACC, a board‑certified preventive cardiologist and the medical director for the Cone Health HeartCare Women’s Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results you’re hoping for, including:

• You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor
• High intake of liquid calories, including alcohol and ultra-processed foods
• Not getting enough protein, which can leave you persistently hungry and makes it harder to feel full
• Advanced diabetes or insulin resistance
• Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain
• Not adhering to your dosing schedule, such as inconsistent weekly injections or missed doses
• Differences in gut hormones or genetics

And just because your GLP-1 isn’t working immediately doesn’t mean it won’t work for you. Dr. Tsang says using a GLP-1 requires practicing self-awareness and patience over time if you expect to lose weight and keep it off. 

“You might notice that you have reduced appetite and food cravings and feel satisfied with smaller portions,” says Dr. Tsang. “You might also notice improved blood sugar readings, better energy or mood and gradual weight loss. All these factors indicate that you possibly just need time or dose adjustment and likely should continue.”

“However, if you have no reduction in appetite after eight to 12 weeks, no weight loss or blood sugar improvement after three to six months or persistent severe side effects that prevent you from going up in dosage, GLP-1s may not be for you,” adds Dr. Tsang. 

Your genes can impact how you respond to a GLP-1 

In a study published in Genome Medicine, researchers found that about 10 percent of people carry certain variants of what’s known as the PAM gene, and those individuals had a weaker blood sugar response to GLP-1–based drugs compared to non-carriers. This suggests the drugs may not work as well for them. And while the study focused on blood sugar control, experts say it may also help explain why some people don’t see the same weight loss results on GLP-1s.

Why? Dr. Tobb explains that the PAM gene helps activate hormones like GLP-1 so they can work properly in the body. If you carry certain variants, your body may not process or “turn on” those hormones as efficiently, leading to weaker GLP-1 signaling. That means even if you’re taking a GLP-1 medication for diabetes or weight management, the body’s response, like insulin release, may be blunted. So the drug is there, but its full effect isn’t.

How much does genetic testing cost?

If you’re hearing about this gene for the first time, you may be wondering how to get tested and what it might cost. Dr. Tobb says the only way to identify a PAM gene variant is through genetic testing, since there are no symptoms or routine lab tests that can detect it. She says this is usually done through broader genetic panels ordered by a doctor, rather than testing for the gene on its own.

“Many cases require prior authorization or are not covered, and out-of-pocket costs generally range from a few hundred dollars for targeted panels to $1,000 to $2,000 for broader panels and several thousand dollars for whole exome or genome sequencing,” says Dr. Tobb.

And while Dr. Tobb says the PAM gene is an interesting example of how genetics can influence weight loss and blood sugar control, she says that most differences in results come down to factors like sleep, medication adherence, diet quality, muscle mass and overall insulin resistance.

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5 Surprising GLP-1 Health Benefits Doctors Want Women 50+ to Know

These days, everyone has heard about GLP-1 drugs like Ozempic and Mounjaro—mostly in connection with weight loss and celebrity transformations. But here’s what doctors and researchers are discovering: These medications do so much more for your health than slim your waistline. In fact, emerging science suggests GLP-1s may support heart health, improve sleep quality and […]

3 GLP-1 alternatives to consider

If you find you’re not responding to GLP-1s,  or if you are seeing results and want to build on them, Dr. Tobb shares three GLP-1 alternatives that may help support blood sugar control and weight loss. Ask your doctor if one of these might be right for you.

Metformin 

Metformin is a first-line oral medication for type 2 diabetes with a long history of data supporting its use. Dr. Tobb explains that it lowers glucose production in the liver and improves insulin sensitivity in the muscles, which can help stabilize blood sugar and helps reduce appetite in some people.

Empagliflozin (or another SGLT2 inhibitor)

This is a once-daily pill that works to support weight loss through the kidneys rather than gut hormones. It helps the body expel excess glucose through urine, Dr. Tobb explains, leading to mild calorie loss, modest weight reduction and improved blood sugar control.

Protein-rich diet 

Dr. Tobb says this eating approach emphasizes protein, fiber and minimally processed carbs and can complement the results you might see on weight loss medications. Protein helps increase satiety hormones, reduces blood sugar spikes after meals and supports muscle mass, which plays a key role in improving insulin sensitivity, she adds.

The bottom line on GLP-1s not working

We get it. When a new health routine or medication seems to work beautifully for everyone else, it’s natural to feel frustrated, or even isolated, when you’re not seeing the same results. But here’s the truth: Your body is unique, and that’s not a flaw.

Understanding why your GLP-1 may not be working as expected is the first step toward finding what will work. Whether it’s adjusting your dosage, giving it more time, exploring alternatives or working with your doctor to try a different approach, you have options to reach your weight-loss goals.

Ready for more inspiration? Subscribe to our YouTube channel for video podcasts, health tips and uplifting stories designed for women 40, 50, 60 and beyond.

If you’ve been curious about weight loss medications but feel overwhelmed by all the options, you’re not alone. With so many popular GLP-1s like Ozempic, Wegovy and Mounjaro making headlines, it’s easy to wonder which one might be right for you. Enter Zepbound—a unique dual-action injectable that tennis superstar Serena Williams has credited as part of her health routine. So what exactly is Zepbound, and what sets it apart from other GLP-1 drugs? We asked a doctor to share everything you need to know about how Zepbound boosts weight loss, who should consider it and how the new KwikPen injectable works.  

What is Zepbound?

Zepbound is a weekly injectable designed to support long-term weight loss by targeting underlying biological drivers of obesity, explains Rekha Kumar, MS, MD, endocrinologist, obesity medicine specialist and Senior Medical Advisor at Found.

“What makes it different is that it activates two hormone pathways, GLP-1 and GIP, which help regulate appetite, metabolism and blood sugar,” adds Dr. Kumar. “That dual mechanism is part of why we see such meaningful results in clinical trials, with patients losing up to about 21 percent of their body weight when combined with lifestyle changes.”

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While often associated with weight loss, Zepbound may also support better blood sugar, cholesterol and blood pressure levels, and it can even help manage conditions like fatty liver and sleep apnea, says Dr. Kumar.

Weight Loss

The Wegovy Pill Is Here: See the Cost and How Much Weight You Can Lose

Been curious about weight-loss medications like Wegovy, but can’t get past the thought of weekly injections? Here’s some game-changing news: A pill version of the popular GLP-1 medication Wegovy is now available—and it currently costs less than weekly injections. Here’s everything you need to know about this new weight-loss option, including how it works, what […]

Is Zepbound right for you? 

Dr. Kumar says it’s typically recommended for:

• Adults with obesity (a BMI of 30 or higher)
• Adults with a BMI of 27 or higher who also have a weight-related condition, such as high cholesterol, high blood pressure or type 2 diabetes

“It’s especially helpful for patients who have made lifestyle changes but still struggle with weight,” adds Dr. Kumar. “The goal is not to replace healthy habits, but to support the biology that often makes weight loss difficult.” Meaning Zepbound works best when paired with a healthy, reduced-calorie diet and increased physical activity. 

Who should avoid Zepbound?

Dr. Kumar adds that Zepbound may not be appropriate for everyone, including those who are pregnant or have a personal or family history of certain conditions such as:

• Medullary thyroid carcinoma, an aggressive type of thyroid cancer
• Multiple endocrine neoplasia syndrome type 2 (MEN2), a rare condition affecting the endocrine system
• Pancreatitis
• Gastrointestinal conditions
• Gallbladder disease

Zepbound is now available in a KwikPen dispenser  

Dr. Kumar says Zepbound is taken as a once-weekly injection under the skin, with patients starting at a lower dose and gradually increasing over time to help minimize side effects. The typical starting dose is 2.5 mg, and it goes up to 15 mg. Zepbound comes in several different forms, including single-dose vials, where the medication must be drawn into a syringe before injection, and prefilled single-use pens that are thrown away after one use.

Eli Lilly has also introduced a newer option called the KwikPen, offering a more streamlined way to take the medication. “The Zepbound KwikPen is a prefilled, multi-dose pen that contains four weekly doses, or about one month of treatment,” explains Dr. Kumar. “Instead of drawing medication into a syringe, patients simply attach a needle, dial their prescribed dose and inject. It’s the same FDA-approved medication, but in a format designed to be simpler and more intuitive to use.”

While the medication itself is unchanged, Dr. Kumar says the KwikPen’s user-friendly design may help patients stick with treatment more consistently, which can lead to better long-term results.

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How much does Zepbound cost?

If you’ve been considering a GLP-1 like Zepbound for weight loss but are hesitant about the potential cost, here’s what to know.  

“Zepbound pricing can vary based on several factors, including your insurance coverage, the dose prescribed and the form factor you’re using—whether that’s the KwikPen, single-dose pen or vial,” says Dr. Kumar. “The version of Zepbound covered by insurance is the single-dose autoinjector, so coverage eligibility will depend on your individual plan. The KwikPen is currently available primarily as a cash-pay option.”

According to Eli Lilly, the KwikPen starts at about $299 per month through its self-pay program for people with a prescription, though the exact price depends on the dose. 

The bottom line on Zepbound for weight loss

Just like weight loss itself, there’s no one-size-fits-all approach when it comes to GLP-1s. But with options like Zepbound and innovations like the KwikPen, finding a treatment that fits your life is more possible than ever. Talk to your doctor about whether Zepbound could be the right next step in your health journey.

Ready for more inspiration? Subscribe to our YouTube channel for video podcasts, health tips and uplifting stories designed for women 40, 50, 60 and beyond.

By now you’ve heard plenty of buzz about GLP-1 medications like Ozempic, Wegovy and Zepbound. Originally developed for type 2 diabetes, these injectable drugs mimic a natural hormone called glucagon-like peptide-1 (GLP1-1) that regulates appetite and blood sugar. Now researchers are studying them for a surprising range of health conditions—and the findings go well beyond managing type 2 diabetes and obesity. Here’s what doctors want you to know about the long-term GLP-1 benefits and the side effects.

GLP-1 benefits for women over 50

The most well-known use of GLP-1 receptor agonist drugs (aside from their original intended use for blood sugar control) is weight management. But emerging research suggests the medications offer impressive health benefits aside from lowering blood sugar levels and supporting weight loss.

Weight Loss

New ‘Triple G’ Retatrutide (‘Reta’) Weight Loss Drug Shows ‘Insane’ Results

Brace yourselves, Ozempic and Zepbound. Eli Lilly just released a jaw-dropping sneak peek from the final phases of testing for retatrutide (nicknamed “Reta”), a brand new GLP-1 weight loss drug that should soon be submitted to the FDA for approval. The average participant getting a 12-mg weekly injection lost 71 pounds in 68 weeks.  “This […]

It protects heart health

The American Heart Association and American Stroke Association now recommend that healthcare professionals consider GLP-1 drugs to reduce stroke risk for certain patients. A study cited in those guidelines found a 20 percent reduction in the risk of heart attack and stroke for people taking a GLP-1, though experts agree that more research is still needed.

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It may help manage fatty liver

There’s promising news on fatty liver disease, too. A study in The New England Journal of Medicine found that 59 percent of patients with NASH (non-alcoholic steatohepatitis) who took a high dose of semaglutide for 72 weeks saw improvement without worsening of fibrosis (or scarring). Ozempic is not currently FDA-approved for fatty liver disease, but some doctors prescribe it off-label for high-risk patients.

It can reverse prediabetes

The results of GLP-1 studies on prediabetes are striking. In the SURMOUNT-1 trial, 95 percent of participants taking tirzepatide reverted to normal blood sugar over 176 weeks, and 99 percent stayed diabetes-free. “There’s not gonna be many people with diabetes left,” said Louis J. Aronne, MD, director of the Comprehensive Weight Control Center at Weill Cornell Medicine.

It may ward off memory loss

Researchers are even looking at the benefits of GLP-1 drugs for brain health. At the 2024 Alzheimer’s Association International Conference, early results showed that people in early stages of Alzheimer’s who took the GLP-1 drug liraglutide daily for a year lost almost 50 percent less brain volume in key areas tied to memory and thinking.

GLP-1 side effects doctors want you to know

While GLP-1s can be game-changers when it comes to treating insulin resistance, regulating blood sugar and helping people achieve significant weight loss, they’re not without risk of side effects. The most common GLP-1 side effects are gastrointestinal upset: nausea, vomiting, diarrhea and constipation. But there are also some lesser-known side effects catching patients off guard.

Headaches are among the most commonly reported side effects, though they aren’t directly triggered by the medication. “If you aren’t eating or drinking regularly, blood sugar can dip, and dehydration can sneak up on you” and trigger head pain, explains Raj Dasgupta, MD, an ABIM Quadruple board-certified physician.

Michael Snyder, MD, Medical Director of the Bariatric Surgery Center at Rose Medical Center, says rapid weight loss can change posture and muscle support, leading to back pain. Temporary hair shedding is a common response to metabolic stress during weight loss. And lower body fat can make some people feel unusually cold.

As for GLP-1 side effects related to vision, a study of more than 16,000 patients published in JAMA Ophthalmology found a higher risk of a rare eye condition called NAION in semaglutide users. But experts say the risk may be more closely linked to underlying conditions like diabetes and obesity than the medication itself. “The majority of people taking these medications do not experience any significant eye issues,” says optometrist Meenal Agarwal, MD.

Good news if you don’t love needles

GLP-1 pills are arriving. The FDA recently approved a once-daily Wegovy pill for weight management. In the OASIS-4 trial, people taking the 25 mg oral semaglutide pill lost about 16.6 percent of their body weight over 64 weeks, compared to 2.7 percent with placebo.

The Wegovy pill costs $149 to $299, compared to $199 to $349 for weekly injections, according to obesity medicine physician Richele Corrado, DO. Eli Lilly’s orforglipron, a second type of GLP-1 pill, is still completing phase three trials, with results expected in the first quarter of 2026. 

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How to get the best results on GLP-1 drugs

Experts say lifestyle changes remain essential alongside GLP-1 treatment to maximize the health benefits of the drug. The World Health Organization recently declared that medications should be used alongside intensive behavioral therapy, not instead of it.

Dr. Corrado advises working with an experienced provider on dose adjustments: “While clinical trials often increase doses every four weeks to the maximum, many real-world patients achieve meaningful results with slower adjustments and without ever reaching the highest dose.”

Talk to your doctor about whether these medications make sense for you. As Dr. Snyder puts it: “Track your symptoms, communicate early with a provider and remember that GLP-1 medications work best when personalized and when managed by your medical team.”

If you’ve been following the weight-loss medication revolution, you’ve likely heard about Wegovy injections. But now there’s a new option that might be even more appealing: a once-daily pill. The FDA recently approved a Wegovy (semaglutide) pill for weight management, giving us an alternative to weekly shots. But how does the pill compare to the injection when it comes to side effects? We asked leading obesity medicine experts to break down everything you need to know about Wegovy pill side effects and how you can manage them at home.

What is the Wegovy pill?

The once-daily Wegovy pill works through the same pathway as injectable semaglutide, says Fatima Cody Stanford, MD, MPH, MPA, MBA, an obesity medicine physician scientist, educator and policy maker at Massachusetts General Brigham and Harvard Medical School. 

“It’s a GLP-1 receptor agonist, meaning it mimics the hormone glucagon-like peptide-1,” she explains. “This hormone helps regulate appetite, slows gastric emptying—the rate at which food leaves the stomach—and enhances insulin secretion in a glucose-dependent manner. The overall physiologic effects are similar to those of the injectable form, though dosing strategies and absorption considerations differ for the oral formulation.”

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Weight Loss

GLP-1 Pills Could Replace Injections—Here's When They'll Be Available

Imagine if losing weight were as simple as swallowing a daily pill—no needles, no injections and no anxiety. If you’re among the 25 percent of adults who fear needles, per Harvard Health, or if self-injecting just doesn’t sound so fun, then this news will feel like a game-changer: GLP-1 pills are in development right now, […]

Common Wegovy pill side effects 

The side effects for the oral pill versus the weekly injection are relatively the same, reveals Richele Corrado, DO, MPH, FACP, an internal and obesity medicine physician at Revolution Medicine, Health & Fitness. Those side effects might include:

• Nausea
• Vomiting
• Diarrhea
• Constipation 
• Abdominal pain or discomfort

One slight caveat: “Clinical trials report one to two percent more nausea with the [Wegovy] pill versus the weekly injection, but so far in clinical practice, I haven’t been seeing that,” she observes.  

“So far at the lower doses, most of my patients have tolerated it well and feel like the hunger and cravings effects are more durable or steady,” she revealed. “Maybe that’s because it’s daily versus weekly. Some people find that the weekly injection effects tend to wear off as the next injection day nears, but that sometimes may be a sign that they just need a higher dose.”

Serious Wegovy pill side effects to watch for

In rare cases, Wegovy may cause side effects including:

• A lump or swelling in your neck
• Hoarseness 
• Trouble swallowing
• Shortness of breath

If you notice any of these warning signs, talk to your doctor to find out if you should stop using Wegovy. The symptoms may potentially be a sign of thyroid cancer. It’s also worth noting that if you or a family member has had medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2), you should avoid taking Wegovy.

Why you might consider the Wegovy pill instead of the injection

The Wegovy pill is another great tool for patients in addition to lifestyle and behavioral changes like healthy eating and regular exercise, Dr. Corrado emphasizes.

“For many of my patients who are already on a weekly injection, most of them aren’t as motivated to switch to a daily pill because they’re used to the weekly injection and the ease of its use. However, for my patients who travel a lot for work, I’ve switched some of them from the weekly injection to the Wegovy pill because it’s easier to travel with since it doesn’t have to remain refrigerated.”

There may also be more appeal for new patients, along with a financial incentive to switch to the pill, she adds. “For those who are new to GLP-1 receptor agonist medications, I think there’s much more interest in taking a daily pill versus a weekly injection. Also, the cost of the oral Wegovy pill is slightly cheaper—$149 to $299 versus $199 to $349 for the weekly Wegovy injections.”

Beyond cost and convenience, Dr. Stanford notes strong patient interest in an oral semaglutide option, largely because many individuals prefer a pill over an injection. For some, needle aversion is a real barrier to treatment, so an oral formulation may reduce hesitation and increase willingness to start therapy, she notes.

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4 ways to ease Wegovy pill side effects

Dr. Stanford emphasizes gradual dose titration as one of the most effective strategies to minimize side effects of the Wegovy pill. The good news? “As with injectables, these symptoms are often temporary and improve as the body adjusts.” Here, she shares a few more helpful approaches:

• Eating smaller, more frequent meals
• Avoiding high-fat or very large meals
• Eating slowly and stopping when you feel full
• Staying well hydrated

Those with a history of gastrointestinal sensitivity may be more prone to nausea, adds Dr. Stanford. “Those who escalate doses too quickly are also at higher risk of side effects. Careful medical supervision and individualized dosing are key.”

The easy timing trick to maximize the benefits of the Wegovy pill

People need to be aware of how to take the oral Wegovy pill appropriately. If they don’t, they won’t absorb it and they’ll be wasting their time and money, cautions Dr. Corrado. “The Wegovy oral pill needs to be taken first thing in the morning with one sip of water. Then you can’t eat, drink or take anything—no other pills—for at least 30 minutes so it can be absorbed properly.”

For anyone who takes levothyroxine (brand name Synthroid), which is a thyroid replacement hormone for hypothyroidism, Dr. Corrado typically recommends taking it right before bed instead so patients can take the Wegovy oral pill in the morning.

The bottom line on Wegovy pill side effects

In short, the potential side effects of the pill form, from nausea and gastrointestinal issues to other common symptoms, are very similar to the injectable version. However, the convenience factor and lower price point may be persuasive reasons to consider the pills, especially if you’re new to GLP-1 medications or have a (totally justifiable!) aversion to needles.

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If you’re one of the millions of women who’ve found success with GLP-1 medications—whether you’ve lost a significant amount of weight or finally gotten your blood sugar under control—you’re probably feeling pretty good about your health journey. And you should! But like any medication, these drugs are still being studied, and new research is giving us important information about how to use them safely. Case in point: A recent study suggests GLP-1 medications may be linked to slightly higher risks of osteoporosis and gout.

But before you start to worry, know this: There are simple, effective steps you can take right now to protect your bone and joint health while continuing to benefit from the medication. We asked top doctors to break down what this research really means for you and share their best tips for staying healthy.

What is osteoporosis?

First, let’s break down what these conditions actually are—because understanding them is the first step to protecting yourself, especially if you’re taking weight-loss drugs like a GLP-1.

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“Osteoporosis is a condition where bones lose density and become more fragile, which increases the risk of fractures,” explains Gina Maccarone, MD, FACS, a triple board-certified cosmetic surgeon and founder of The Surgeonista. “Bone is constantly being broken down and rebuilt. But as we age, that rebuilding process slows, and if bone loss outpaces bone formation, the skeleton gradually becomes weaker. Hormonal changes, especially after menopause, along with genetics, low calcium or vitamin D intake, certain medications and lack of weight-bearing exercise can all contribute to the development of osteoporosis over time.”

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What is gout?

“Gout is a form of inflammatory arthritis caused by a buildup of uric acid in the bloodstream,” says Dr. Maccarone. “When uric acid [bodily waste] levels get too high, it can form tiny crystals that deposit in the joints and trigger sudden, painful inflammation, often in the big toe but sometimes in the ankle, knee or other joints. Genetics, kidney function, diet, alcohol, certain medications and metabolic conditions all play a role. For most people, it’s not just one trigger, but a combination of factors that pushes uric acid levels high enough to cause a flare.”

How GLP-1s can affect osteoporosis and gout risk 

According to NBC News, at the American Academy of Orthopaedic Surgeons’ 2026 meeting, researchers presented findings from a new unpublished study that analyzed medical records from over 146,000 adults living with type 2 diabetes and obesity, comparing those who used GLP-1 medications with those who did not over a five-year period. The researchers found that nearly four percent of GLP-1 users developed osteoporosis, putting them at nearly a 30 percent higher risk compared to people who did not take the drugs. Gout rates were also slightly higher, with 7 percent of GLP-1 users developing the condition, putting them at nearly a 12 percent higher risk than those who did not use the medications.

“Readers should see this research as early observational data, not an ironclad proof that GLP-1 medicines directly contribute to osteoporosis or gout,” reassures Timur Alptunaer, MD, a board-certified emergency medicine physician in Washington, D.C. “That said, studies such as this one help researchers spot trends that need further examination.”

“What this research really reinforces is that weight-loss medications should be used with medical guidance so clinicians can monitor nutrition, muscle mass and overall metabolic health along the way,” adds Dr. Maccarone. “The goal isn’t simply losing weight quickly, it’s losing weight in a way that supports long-term health.”

4 ways to lower gout and osteoporosis risk 

If this new research has you feeling concerned, take a deep breath. Both Dr. Maccarone and Dr. Alptunaer emphasize that you should not stop taking your GLP-1 without talking to your doctor first, as abruptly stopping medication could have adverse risks on your health. If your doctor advises that you continue taking your GLP-1 drugs, here’s how to protect your bones and joints in the process: 

• Prioritize protein: Dr. Maccarone says getting enough protein is important while losing weight because it supports your overall metabolism and helps you preserve muscle mass.
• Get active:  “Strength training and weight-bearing exercise are also key because bones respond to load and movement, which helps maintain bone density,” says Dr. Maccarone. 
• Take these vitamins: Both Dr. Maccarone and Dr. Alptunaer recommend adding vitamin D and calcium to your routine to support bone health. 
• Stay hydrated: As for gout, Dr. Maccarone adds that staying hydrated can help keep uric acid levels in a healthy range, which may lower the risk of this condition. 

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The bottom line 

If you’re taking a GLP-1 medication, you’re already taking an important step toward better health. This new research simply gives you more information to work with—and more ways to protect yourself. By staying informed, working closely with your doctor and following these simple bone- and joint-health strategies, you can continue to benefit from your medication while supporting your body.